Brian Smith
Managing Director at S3 Ventures
Austin, Texas
Overview
Work Experience
Managing Director
2005 - Current
S3 Ventures is the largest venture firm focused on Texas with over $900 million under management. We invest in Seed, Series A and B business technology, healthcare technology and digital experience companies. We have a unique single LP funding model that supports entrepreneurs as they seek to build great companies.
Board of Directors
2025
Endovascular Engineering, Inc. (“E2”), is a mission-driven, venture-backed company focused on the development and deployment of next generation clot removal technologies that target venous thromboembolism.
Board of Directors
2024
Image Without Compromise. The HyperVue Imaging System brings next generation intravascular imaging to your cath lab with powerful images and simplified workflows.
Spectrawave is a medical device company that develops optical diagnostic and therapeutic devices.
Raised $79,597,066.00 from Deerfield Management, Nova Ventures, Johnson & Johnson Innovation – JJDC, Heartwork Capital, S3 Ventures, SV Health Investors and Lumira Ventures.
Board of Directors
2016
For enterprises competing in today's application economy, Datical accelerates release cycles by making database deployments as agile as the application.
Board of Directors
2014
VUV makes universal detectors that bring gas analytics out of the dark ages.
Board of Directors
2011
The next generation of online and mobile banking.
Alkami Technology provides cloud-based digital banking solutions for credit unions and banks.
Raised $385,182,200.00 from D1 Capital Partners, Fidelity, Stockbridge Investors and Franklin Templeton.
Board of Directors
2021 - 2024
Saranas invented the Early Bird, the first and only FDA-approved bleed detection system for peri and post-procedural monitoring of endovascular procedures, providing accurate and actionable information before it is too late.
Saranas develops a medical device that detects internal bleeding during catheterization procedures.
Raised $29,177,420.00 from S3 Ventures and Baird Capital.
Board of Directors
2010 - 2021
Health Benefits Optimization via Software and services enabling the large-scale shift to consumer directed healthcare.
Board Of Directors
2017 - 2020
Acessa is a minimally invasive, uterine-sparing solution for fibroids. FDA cleared Acessa addresses all fibroid locations, is outpatient and women are better in days vs. weeks with other methods. Acessa was acquired in August, 2020 by Hologic (Nasdaq:HOLX).
Investor
2017 - 2020
Liveoak enables global enterprises to do business with their customers without being in person.
Liveoak is a computer software company that specializes in cloud-based platform.
Raised $13,575,000.00 from Northwestern Mutual Future Ventures, S3 Ventures, Wild Basin Investments, Seven Peaks Ventures, Broadhaven Capital Partners, State Farm Ventures and Techstars.