BS

Brian Smith

Managing Director at S3 Ventures

Austin, Texas

Overview 

Brian Smith is the Managing Director at S3 Ventures in Austin, Texas, overseeing investments in early-stage ventures and growth acceleration. With a background in investment management and a track record of successful board positions in various companies like VUV Analytics, Alkami Technology, and Saranas, he has demonstrated strong business acumen and a strategic approach to fostering entrepreneurship and strategic partnerships.

Work Experience 

  • Managing Director

    2005 - Current

    S3 Ventures is the largest venture firm focused on Texas with over $900 million under management. We invest in Seed, Series A and B business technology, healthcare technology and digital experience companies. We have a unique single LP funding model that supports entrepreneurs as they seek to build great companies.

  • Board of Directors

    2025

    Endovascular Engineering, Inc. (“E2”), is a mission-driven, venture-backed company focused on the development and deployment of next generation clot removal technologies that target venous thromboembolism.

  • Board of Directors

    2024

    Image Without Compromise. The HyperVue Imaging System brings next generation intravascular imaging to your cath lab with powerful images and simplified workflows.

Spectrawave is a medical device company that develops optical diagnostic and therapeutic devices.

Raised $79,597,066.00 from Deerfield Management, Nova Ventures, Johnson & Johnson Innovation – JJDC, Heartwork Capital, S3 Ventures, SV Health Investors and Lumira Ventures.

  • Board of Directors

    2016

    For enterprises competing in today's application economy, Datical accelerates release cycles by making database deployments as agile as the application.

  • Board of Directors

    2014

    VUV makes universal detectors that bring gas analytics out of the dark ages.

  • Board of Directors

    2011

    The next generation of online and mobile banking.

Alkami Technology provides cloud-based digital banking solutions for credit unions and banks.

Raised $385,182,200.00 from D1 Capital Partners, Fidelity, Stockbridge Investors and Franklin Templeton.

  • Board of Directors

    2021 - 2024

    Saranas invented the Early Bird, the first and only FDA-approved bleed detection system for peri and post-procedural monitoring of endovascular procedures, providing accurate and actionable information before it is too late.

Saranas develops a medical device that detects internal bleeding during catheterization procedures.

Raised $29,177,420.00 from S3 Ventures and Baird Capital.

  • Board of Directors

    2010 - 2021

    Health Benefits Optimization via Software and services enabling the large-scale shift to consumer directed healthcare.

  • Board Of Directors

    2017 - 2020

    Acessa is a minimally invasive, uterine-sparing solution for fibroids. FDA cleared Acessa addresses all fibroid locations, is outpatient and women are better in days vs. weeks with other methods. Acessa was acquired in August, 2020 by Hologic (Nasdaq:HOLX).

  • Investor

    2017 - 2020

    Liveoak enables global enterprises to do business with their customers without being in person.

Liveoak is a computer software company that specializes in cloud-based platform.

Raised $13,575,000.00 from Northwestern Mutual Future Ventures, S3 Ventures, Wild Basin Investments, Seven Peaks Ventures, Broadhaven Capital Partners, State Farm Ventures and Techstars.

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