JH

Jon H. Smith

Principal at 645 Ventures

San Francisco, California

Overview 

Jon H. Smith is currently a Principal at 645 Ventures in San Francisco, with a background that includes roles at Nickson Living, Goldman Sachs, and GE Capital. With experience as a Venture Fellow and Senior Associate, he has successfully navigated the venture capital landscape and contributed to the growth of various companies.

Work Experience 

  • Principal

    2024 - Current

    Leading the firm's healthcare and proptech investing practices. Looking to lead seed and series a rounds. Sourced Investments: Setpoint, Efficient Capital Labs, Aryeo (acq.), Crescendo Health, Upside, InpharmD, Haplotype Labs, and Condor.

  • Vice President

    2023 - 2024

  • Senior Associate

    2021 - 2023

  • Venture Fellow

    2021 - 2021

645 Ventures partners with exceptional founders at Seed and Series A to build iconic companies that scale to the growth stage.

  • Founding Member

    2017 - 2019

  • Structured Finance

    2015 - 2017

Goldman Sachs is a multinational financial services firm providing securities, investment banking, and management services.

  • Financial Management Program

    2014 - 2015

GE Commercial Finance is one of General Electric's largest growth engines.

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